Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras

Antigen-presenting cells (APCs) of host origin drive graft-versus-leukemia (GVL) effects but can also trigger life-threatening graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT) across major histocompatibility complex (MHC) barriers. We show that in vitro priming of dono...

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Detalhes bibliográficos
Main Authors: Ghosh, Arnab, Koestner, Wolfgang, Hapke, Martin, Schlaphoff, Verena, Länger, Florian, Baumann, Rolf, Koenecke, Christian, Cornberg, Markus, Welte, Karl, Blazar, Bruce R., Sauer, Martin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676097/
https://ncbi.nlm.nih.gov/pubmed/19182207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-181677
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