CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy

The interaction of multiple myeloma (MM) cells with their microenvironment in the bone marrow (BM) provides a protective environment and resistance to therapeutic agents. We hypothesized that disruption of the interaction of MM cells with their BM milieu would lead to their sensitization to therapeu...

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Main Authors: Azab, Abdel Kareem, Runnels, Judith M., Pitsillides, Costas, Moreau, Anne-Sophie, Azab, Feda, Leleu, Xavier, Jia, Xiaoying, Wright, Renee, Ospina, Beatriz, Carlson, Alicia L., Alt, Clemens, Burwick, Nicholas, Roccaro, Aldo M., Ngo, Hai T., Farag, Mena, Melhem, Molly R., Sacco, Antonio, Munshi, Nikhil C., Hideshima, Teru, Rollins, Barrett J., Anderson, Kenneth C., Kung, Andrew L., Lin, Charles P., Ghobrial, Irene M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676090/
https://ncbi.nlm.nih.gov/pubmed/19139079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-186668
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