RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma

The interaction of multiple myeloma (MM) cells with the bone marrow (BM) milieu plays a crucial role in MM pathogenesis. Stromal cell–derived factor-1 (SDF1) regulates homing of MM cells to the BM. In this study, we examined the role of RhoA and Rac1 GTPases in SDF1-induced adhesion and chemotaxis o...

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Detalhes bibliográficos
Main Authors: Azab, Abdel Kareem, Azab, Feda, Blotta, Simona, Pitsillides, Costas M., Thompson, Brian, Runnels, Judith M., Roccaro, Aldo M., Ngo, Hai T., Melhem, Molly R., Sacco, Antonio, Jia, Xiaoying, Anderson, Kenneth C., Lin, Charles P., Rollins, Barrett J., Ghobrial, Irene M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713475/
https://ncbi.nlm.nih.gov/pubmed/19443661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-199281
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