PapA3 Is an Acyltransferase Required for Polyacyltrehalose Biosynthesis in Mycobacterium tuberculosis

Mycobacterium tuberculosis possesses an unusual cell wall that is replete with virulence-enhancing lipids. One cell wall molecule unique to pathogenic M. tuberculosis is polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid. Little is known about the biosynthesis of PAT, although its...

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Hlavní autoři: Hatzios, Stavroula K., Schelle, Michael W., Holsclaw, Cynthia M., Behrens, Christopher R., Botyanszki, Zsofia, Lin, Fiona L., Carlson, Brian L., Kumar, Pawan, Leary, Julie A., Bertozzi, Carolyn R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676004/
https://ncbi.nlm.nih.gov/pubmed/19276083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809088200
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