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Direct Observation of ATP-Induced Conformational Changes in Single P2X(4) Receptors

The ATP-gated P2X(4) receptor is a cation channel, which is important in various pathophysiological events. The architecture of the P2X(4) receptor in the activated state and how to change its structure in response to ATP binding are not fully understood. Here, we analyze the architecture and ATP-in...

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Detalhes bibliográficos
Main Authors: Shinozaki, Youichi, Sumitomo, Koji, Tsuda, Makoto, Koizumi, Schuichi, Inoue, Kazuhide, Torimitsu, Keiichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675908/
https://ncbi.nlm.nih.gov/pubmed/19419241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000103
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