Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

BACKGROUND: Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this...

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Bibliografiska uppgifter
Huvudupphovsmän: van den Biggelaar, Maartje, Bouwens, Eveline A.M., Kootstra, Neeltje A., Hebbel, Robert P., Voorberg, Jan, Mertens, Koen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Ferrata Storti Foundation 2009
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675679/
https://ncbi.nlm.nih.gov/pubmed/19336741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.13427
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