Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns

Cytosine methylation patterns are essential for the proper control of gene expression in higher vertebrates. Although alterations in methylation patterns are frequently observed in human tumors, neither the mechanisms for establishing methylation patterns during normal development nor the mechanisms...

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Bibliographic Details
Main Authors: Lao, Victoria Valinluck, Herring, Jason L., Kim, Cherine H., Darwanto, Agus, Soto, Ubaldo, Sowers, Lawrence C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Carcinogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675655/
https://ncbi.nlm.nih.gov/pubmed/19279184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp060
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