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Interleukin-13–induced MUC5AC Is Regulated by 15-Lipoxygenase 1 Pathway in Human Bronchial Epithelial Cells

Rationale: 15-Lipoxygenase-1 (15LO1) and MUC5AC are highly expressed in asthmatic epithelial cells. IL-13 is known to induce 15LO1 and MUC5AC in human airway epithelial cells in vitro. Whether 15LO1 and/or its product 15-HETE modulate MUC5AC expression is unknown. Objectives: To determine the expres...

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Main Authors: Zhao, Jinming, Maskrey, Ben, Balzar, Silvana, Chibana, Kazuyuki, Mustovich, Anthony, Hu, Haizhen, Trudeau, John B., O'Donnell, Valerie, Wenzel, Sally E.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675565/
https://ncbi.nlm.nih.gov/pubmed/19218191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200811-1744OC
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