Aprotinin Exerts Differential and Dose Dependent Effects on Myocardial Contractility, Oxidative Stress and Cytokine Release Following Ischemia-Reperfusion

BACKGROUND: Cardiac surgery can result in LV ischemia and reperfusion (I/R), the release of cytokines such as tumor necrosis factor, and oxidative-stress with release of myeloperoxidase. While aprotinin has been used in cardiac surgery, the likely multiple effects of this serine protease inhibitor l...

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Main Authors: McEvoy, Matthew D., Taylor, Anna-Greta, Zavadzkas, Juozas A., Mains, Ira M., Ford, Rachael A., Stroud, Robert E., Jeffords, Laura B., Beck, Christy U., Reeves, Scott T., Spinale, Francis G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675543/
https://ncbi.nlm.nih.gov/pubmed/18640335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2008.04.025
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