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The effects of membrane potential, SR Ca(2+) content and RyR responsiveness on systolic Ca(2+) alternans in rat ventricular myocytes

Previous work has shown that small depolarizing pulses produce a beat to beat alternation in the amplitude of the systolic Ca(2+) transient in ventricular myocytes. The aim of the present work was to investigate the role of changes of SR Ca(2+) content and L-type Ca(2+) current in this alternans. As...

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Detalhes bibliográficos
Main Authors: Li, Yatong, Díaz, Mary E, Eisner, David A, O'Neill, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674997/
https://ncbi.nlm.nih.gov/pubmed/19153161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.164368
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