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The effects of membrane potential, SR Ca(2+) content and RyR responsiveness on systolic Ca(2+) alternans in rat ventricular myocytes

Previous work has shown that small depolarizing pulses produce a beat to beat alternation in the amplitude of the systolic Ca(2+) transient in ventricular myocytes. The aim of the present work was to investigate the role of changes of SR Ca(2+) content and L-type Ca(2+) current in this alternans. As...

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Hlavní autoři: Li, Yatong, Díaz, Mary E, Eisner, David A, O'Neill, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674997/
https://ncbi.nlm.nih.gov/pubmed/19153161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.164368
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