Requirement for Ca(2+)/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice

Ca(2+)/calmodulin–dependent kinase II (CaMKII) has been implicated in cardiac hypertrophy and heart failure. We generated mice in which the predominant cardiac isoform, CaMKIIδ, was genetically deleted (KO mice), and found that these mice showed no gross baseline changes in ventricular structure or...

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Détails bibliographiques
Auteurs principaux: Ling, Haiyun, Zhang, Tong, Pereira, Laetitia, Means, Christopher Kable, Cheng, Hongqiang, Gu, Yusu, Dalton, Nancy D., Peterson, Kirk L., Chen, Ju, Bers, Donald, Heller Brown, Joan
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673879/
https://ncbi.nlm.nih.gov/pubmed/19381018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38022
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