Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that Δ(9)-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data...

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Detalhes bibliográficos
Main Authors: Salazar, María, Carracedo, Arkaitz, Salanueva, Íñigo J., Hernández-Tiedra, Sonia, Lorente, Mar, Egia, Ainara, Vázquez, Patricia, Blázquez, Cristina, Torres, Sofía, García, Stephane, Nowak, Jonathan, Fimia, Gian María, Piacentini, Mauro, Cecconi, Francesco, Pandolfi, Pier Paolo, González-Feria, Luis, Iovanna, Juan L., Guzmán, Manuel, Boya, Patricia, Velasco, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673842/
https://ncbi.nlm.nih.gov/pubmed/19425170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37948
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