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Identification of Mycobacterium tuberculosis vaccine candidates using human CD4(+) T-cells expression cloning

To identify Mycobacterium tuberculosis (Mtb) antigens as candidates for a subunit vaccine against tuberculosis (TB), we have employed a CD4(+) T-cell expression screening method. Mtb-specific CD4(+) T-cell lines from nine healthy PPD positive donors were stimulated with different antigenic substrate...

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Detalhes bibliográficos
Main Authors: Coler, Rhea N., Dillon, Davin C., Skeiky, Yasir A. W., Kahn, Maria, Orme, Ian M., Lobet, Yves, Reed, Steven G., Alderson, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673800/
https://ncbi.nlm.nih.gov/pubmed/19000730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.10.056
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