ABNORMAL REGULATORY AND EFFECTOR T CELL FUNCTION PREDISPOSE TO AUTOIMMUNITY FOLLOWING XENOGENEIC THYMIC TRANSPLANTATION

Porcine thymus grafts support robust murine and human thymopoiesis, generating a diverse T cell repertoire that is deleted of donor and host-reactive cells, achieving specific xenograft tolerance. Positive selection is mediated exclusively by the xenogeneic thymic MHC. While thymectomized, T cell-de...

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Hlavní autoři: Fudaba, Yasuhiro, Onoe, Takashi, Chittenden, Meredith, Shimizu, Akira, Shaffer, Juanita M., Bronson, Roderick, Sykes, Megan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673578/
https://ncbi.nlm.nih.gov/pubmed/19017953
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