Calpain Hydrolysis of α- and β2-Adaptins Decreases Clathrin-dependent Endocytosis and May Promote Neurodegeneration

Clathrin-dependent endocytosis is mediated by a tightly regulated network of molecular interactions that provides essential protein-protein and protein-lipid binding activities. Here we report the hydrolysis of the α- and β2-subunits of the tetrameric adaptor protein complex 2 by calpain. Calcium-de...

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Main Authors: Rudinskiy, Nikita, Grishchuk, Yulia, Vaslin, Anne, Puyal, Julien, Delacourte, André, Hirling, Harald, Clarke, Peter G. H., Luthi-Carter, Ruth
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673311/
https://ncbi.nlm.nih.gov/pubmed/19240038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804740200
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