A phosphatidylinositol (4,5)-bisphosphate binding site within μ2-adaptin regulates clathrin-mediated endocytosis

The clathrin adaptor complex AP-2 serves to coordinate clathrin-coated pit assembly with the sorting of transmembrane cargo proteins at the plasmalemma. How precisely AP-2 assembly and cargo protein recognition at sites of endocytosis are regulated has remained unclear, but recent evidence implicate...

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Main Authors: Rohde, Gundula, Wenzel, Dirk, Haucke, Volker
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173125/
https://ncbi.nlm.nih.gov/pubmed/12119359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200203103
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