Transforming Growth Factor-β/Smad3 Signaling Regulates Insulin Gene Transcription and Pancreatic Islet β-Cell Function

Pancreatic islet β-cell dysfunction is a signature feature of Type 2 diabetes pathogenesis. Consequently, knowledge of signals that regulate β-cell function is of immense clinical relevance. Transforming growth factor (TGF)-β signaling plays a critical role in pancreatic development although the rol...

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Bibliographische Detailangaben
Hauptverfasser: Lin, Huei-Min, Lee, Ji-Hyeon, Yadav, Hariom, Kamaraju, Anil K., Liu, Eric, Zhigang, Duan, Vieira, Anthony, Kim, Seong-Jin, Collins, Heather, Matschinsky, Franz, Harlan, David M., Roberts, Anita B., Rane, Sushil G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Molecular Basis of Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673293/
https://ncbi.nlm.nih.gov/pubmed/19265200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805379200
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