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Expanded hammerhead ribozymes containing addressable three-way junctions

Recently, hammerhead ribozyme (HHR) motifs have been utilized as powerful tools for gene regulation. Here we present a novel design of expanded full-length HHRs that allows attaching additional functionalities to the ribozyme. These features allowed us to construct a very efficient artificial ribosw...

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Autores principales: Wieland, Markus, Gfell, Manuela, Hartig, Jörg S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673082/
https://ncbi.nlm.nih.gov/pubmed/19304923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1220309
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