A Complex Extracellular Sphingomyelinase of Pseudomonas aeruginosa Inhibits Angiogenesis by Selective Cytotoxicity to Endothelial Cells

The hemolytic phospholipase C (PlcHR) expressed by Pseudomonas aeruginosa is the original member of a Phosphoesterase Superfamily, which includes phosphorylcholine-specific phospholipases C (PC-PLC) produced by frank and opportunistic pathogens. PlcHR, but not all its family members, is also a poten...

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Bibliographic Details
Main Authors: Vasil, Michael L., Stonehouse, Martin J., Vasil, Adriana I., Wadsworth, Sandra J., Goldfine, Howard, Bolcome, Robert E., Chan, Joanne
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673038/
https://ncbi.nlm.nih.gov/pubmed/19424430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000420
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