Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p

Genome sequencing dramatically increased our ability to understand cellular response to perturbation. Integrating system-wide measurements such as gene expression with networks of protein–protein interactions and transcription factor binding revealed critical insights into cellular behavior. However...

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Main Authors: Moxley, Joel F., Jewett, Michael C., Antoniewicz, Maciek R., Villas-Boas, Silas G., Alper, Hal, Wheeler, Robert T., Tong, Lily, Hinnebusch, Alan G., Ideker, Trey, Nielsen, Jens, Stephanopoulos, Gregory
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Complex Systems: From Chemistry to Systems Biology Special Feature
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672541/
https://ncbi.nlm.nih.gov/pubmed/19346491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811091106
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