The actin regulator coronin-1A is mutated in a thymic egress deficient mouse strain and in a T(−)B(+)NK(+) SCID patient

Mice carrying the recessive peripheral T cell deficiency (Ptcd) locus have a block in thymic egress but the mechanism responsible is undefined. Here we found that Ptcd T cells have an intrinsic migration defect, impaired lymphoid tissue trafficking and irregularly shaped protrusions. Characterizatio...

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Main Authors: Shiow, Lawrence R., Roadcap, David W., Paris, Kenneth, Watson, Susan R., Grigorova, Irina L., Lebet, Tonya, An, Jinping, Xu, Ying, Jenne, Craig N., Föger, Niko, Sorensen, Ricardo U., Goodnow, Christopher C., Bear, James E., Puck, Jennifer M., Cyster, Jason G.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672406/
https://ncbi.nlm.nih.gov/pubmed/18836449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1662
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