Adverse Effects of a Clinically Relevant Dose of Hydroxyurea Used for the Treatment of Sickle Cell Disease on Male Fertility Endpoints

Two experiments were conducted to determine: 1) whether the adult male transgenic sickle cell mouse (Tg58 × Tg98; TSCM), exhibits the patterns of reproductive endpoints (hypogonadism) characteristic of men with sickle cell disease (SCD) and 2) whether hydroxyurea (HU) exacerbates this condition. In...

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Autori principali: Jones, Kea M., Niaz, Mohammad S., Brooks, Cynthia M., Roberson, Shannon I., Aguinaga, Maria P., Hills, Edward R., Rice, Valerie Montgomery, Bourne, Phillip, Bruce, Donald, Archibong, Anthony E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Molecular Diversity Preservation International (MDPI) 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672375/
https://ncbi.nlm.nih.gov/pubmed/19440437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijerph6031124
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