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PTH and PTH Antagonist Induce Different Conformational Changes in the PTHR1 Receptor

Interaction of ligands with their specific receptors is accompanied by conformational shifts culminating in receptor activation and expression of hormonal activity. Using an engineered disulfide bond formation strategy, we characterized the relative conformational changes taking place within the PTH...

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Detalhes bibliográficos
Main Authors: Thomas, Beena E., Sharma, Sandhya, Mierke, Dale F., Rosenblatt, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Amer Soc Bone & Mineral Res. 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672208/
https://ncbi.nlm.nih.gov/pubmed/19063682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.081228
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