Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas

CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development. CYP1B1 was not detectable in cultured embryonic fibroblast (...

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Autors principals: Buters, Jeroen T. M., Sakai, Shuichi, Richter, Thomas, Pineau, Thierry, Alexander, David L., Savas, Uzen, Doehmer, Johannes, Ward, Jerrold M., Jefcoate, Colin R., Gonzalez, Frank J.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC26722/
https://ncbi.nlm.nih.gov/pubmed/10051580
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