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Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches

Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark lesions were purified and their protein constituents identified, precipitating an avalanche of molecular...

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Detalhes bibliográficos
Main Authors: Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672036/
https://ncbi.nlm.nih.gov/pubmed/19399255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms10031386
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