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Amyloid-β in Alzheimer's disease: the horse or the cart? Pathogenic or protective?

While the pathogenesis of Alzheimer's disease (AD) is unclear, amyloid-β plaques remain major lesions in the brain of individuals with AD. Likewise, amyloid-β is one of the best-studied proteins relating to the pathogenesis of AD. Indeed, the pathological diagnosis of AD tends to be congruous w...

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Autors principals: Lee, Hyoung-Gon, Castellani, Rudy J, Zhu, Xiongwei, Perry, George, Smith, Mark A
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517413/
https://ncbi.nlm.nih.gov/pubmed/15910547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.0959-9673.2005.00429.x
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