Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons

BACKGROUND: Amyotrophic lateral sclerosis (ALS), the most frequent adult onset motor neuron disease, is associated with hypermetabolism linked to defects in muscle mitochondrial energy metabolism such as ATP depletion and increased oxygen consumption. It remains unknown whether muscle abnormalities...

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Detalhes bibliográficos
Principais autores: Dupuis, Luc, Gonzalez de Aguilar, Jose-Luis, Echaniz-Laguna, Andoni, Eschbach, Judith, Rene, Frédérique, Oudart, Hugues, Halter, Benoit, Huze, Caroline, Schaeffer, Laurent, Bouillaud, Frédéric, Loeffler, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671839/
https://ncbi.nlm.nih.gov/pubmed/19404401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005390
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