Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice

Cell-penetrating peptides (CPPs), containing arginine (R), 6-aminohexanoic acid (X), and/or β-alanine (B) conjugated to phosphorodiamidate morpholino oligomers (PMOs), enhance their delivery in cell culture. In this study, the potency, functional biodistribution, and toxicity of these conjugates wer...

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Hlavní autoři: Jearawiriyapaisarn, Natee, Moulton, Hong M, Buckley, Brian, Roberts, Jennifer, Sazani, Peter, Fucharoen, Suthat, Iversen, Patrick L, Kole, Ryszard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671676/
https://ncbi.nlm.nih.gov/pubmed/18545222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.120
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