LDH-A Inhibition, a therapeutic strategy for treatment of Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC)

The genetic basis for the Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) syndrome is germline inactivating mutation in the gene for the Krebs/tricarboxylic acid (TCA) cycle enzyme, fumarate hydratase (FH), the enzyme that converts fumarate to malate. These individuals are predisposed to dev...

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Hlavní autoři: Xie, Han, Valera, Vladimir A., Merino, Maria J., Amato, Angela M., Signoretti, Sabina, Linehan, W. M, Sukhatme, Vikas P., Seth, Pankaj
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671637/
https://ncbi.nlm.nih.gov/pubmed/19276158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1049
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