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Structure and function in rhodopsin: Further elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and function

The disulfide bond between Cys-110 and Cys-187 in the intradiscal domain is required for correct folding in vivo and function of mammalian rhodopsin. Misfolding in rhodopsin, characterized by the loss of ability to bind 11-cis-retinal, has been shown to be caused by an intradiscal disulfide bond dif...

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Библиографические подробности
Главные авторы: Hwa, John, Reeves, Philip J., Klein-Seetharaman, Judith, Davidson, Florence, Khorana, H. Gobind
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 1999
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC26714/
https://ncbi.nlm.nih.gov/pubmed/10051572
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