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IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas
IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in 12% of glioblastomas. We assessed IDH1 mutations in 321 gliomas of various histological types and biological behaviors. A total of 130 IDH1 mutations was detected, and all...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Investigative Pathology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671348/ https://ncbi.nlm.nih.gov/pubmed/19246647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080958 |
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