IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in 12% of glioblastomas. We assessed IDH1 mutations in 321 gliomas of various histological types and biological behaviors. A total of 130 IDH1 mutations was detected, and all...

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Bibliographic Details
Main Authors: Watanabe, Takuya, Nobusawa, Sumihito, Kleihues, Paul, Ohgaki, Hiroko
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2009
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Short Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671348/
https://ncbi.nlm.nih.gov/pubmed/19246647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080958
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