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IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in 12% of glioblastomas. We assessed IDH1 mutations in 321 gliomas of various histological types and biological behaviors. A total of 130 IDH1 mutations was detected, and all...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Watanabe, Takuya, Nobusawa, Sumihito, Kleihues, Paul, Ohgaki, Hiroko
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Investigative Pathology 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671348/
https://ncbi.nlm.nih.gov/pubmed/19246647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080958
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