Global Levels of Histone Modifications Predict Prognosis in Different Cancers

Cancer cells exhibit alterations in histone modification patterns at individual genes and globally at the level of single nuclei in individual cells. We demonstrated previously that lower global/cellular levels of histone H3 lysine 4 dimethylation (H3K4me2) and H3K18 acetylation (ac) predict a highe...

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Autors principals: Seligson, David B., Horvath, Steve, McBrian, Matthew A., Mah, Vei, Yu, Hong, Tze, Sheila, Wang, Qun, Chia, David, Goodglick, Lee, Kurdistani, Siavash K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2009
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671251/
https://ncbi.nlm.nih.gov/pubmed/19349354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080874
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