Antiseizure Activity of Novel Gamma-Aminobutyric Acid (A) Receptor Subtype-Selective Benzodiazepine Analogs in Mice and Rat Models

The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described. These BDZs have selective efficacy for α2β3γ2 and α3β3γ2 GABA(A)-receptors. Significant anticonvulsant activity with little or no motor impairment and therapeutic indexes (TI) of 2.8-44 (mice, ip)...

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Auteurs principaux: Rivas, Felix M., Stables, James P., Murphree, Lauren, Edwankar, Rahul V., Edwankar, Chitra R., Huang, Shengming, Jain, Hiteshkumar D., Zhou, Hao, Majumder, Samarpan, Sankar, Subramanian, Roth, Bryan L., Ramerstorfer, Joachim, Furtmuller, Roman, Sieghart, Werner, Cook, James M.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671240/
https://ncbi.nlm.nih.gov/pubmed/19275170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801652d
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