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alpha-Sarcin catalytic activity is not required for cytotoxicity

BACKGROUND: α-Sarcin is a protein toxin produced by Aspergillus giganteus. It belongs to a family of cytotoxic ribonucleases that inactivate the ribosome and inhibit protein synthesis. α-Sarcin cleaves a single phosphodiester bond within the RNA backbone of the large ribosomal subunit, which makes t...

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Bibliografski detalji
Glavni autori: Alford, Spencer C, Pearson, Joel D, Carette, Amanda, Ingham, Robert J, Howard, Perry L
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670844/
https://ncbi.nlm.nih.gov/pubmed/19344516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-10-9
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