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Substitution of histidine-137 by glutamine abolishes the catalytic activity of the ribosome-inactivating protein alpha-sarcin.

The alpha-sarcin cytotoxin is an extracellular fungal protein that inhibits protein biosynthesis by specifically cleaving one phosphodiester bond of the 28 S rRNA. The His137 residue of alpha-sarcin is suggested to be involved in the catalytic activity of this protein, based on the observed sequence...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lacadena, J, Mancheño, J M, Martinez-Ruiz, A, Martínez del Pozo, A, Gasset, M, Oñaderra, M, Gavilanes, J G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1135770/
https://ncbi.nlm.nih.gov/pubmed/7626023
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