tRNA(Val)-heterodimeric maxizymes with high potential as geneinactivating agents: Simultaneous cleavage at two sites in HIV-1 tat mRNA in cultured cells

It has been demonstrated that shortened forms of (stem II-deleted) hammerhead ribozymes with low intrinsic activity form very active dimers with a common stem II (very active short ribozymes capable of forming dimers were designated maxizymes). Intracellular activities of heterodimeric maxizymes and...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kuwabara, Tomoko, Warashina, Masaki, Nakayama, Aya, Ohkawa, Jun, Taira, Kazunari
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26706/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051564/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.1886
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