Thieno[2,3-c]Isoquinolin-5-one, a Potent Poly(ADP-Ribose) Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High-Fat Diet-Fed Apolipoprotein E-Deficient Mice: Effects on Inflammatory Markers and Lipid Content

We recently showed that poly(ADP-ribose) polymerase (PARP) is activated within atherosclerotic plaques in an animal model of atherosclerosis. Pharmacological inhibition of PARP or reduced expression in heterozygous animals interferes with atherogenesis and may promote factors of plaque stability, po...

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Main Authors: Hans, Chetan P., Zerfaoui, Mourad, Naura, Amarjit S., Troxclair, Dana, Strong, Jack P., Matrougui, Khalid, Boulares, A. Hamid
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Cardiovascular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670599/
https://ncbi.nlm.nih.gov/pubmed/19124646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.145938
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