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Thieno[2,3-c]Isoquinolin-5-one, a Potent Poly(ADP-Ribose) Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High-Fat Diet-Fed Apolipoprotein E-Deficient Mice: Effects on Inflammatory Markers and Lipid Content

We recently showed that poly(ADP-ribose) polymerase (PARP) is activated within atherosclerotic plaques in an animal model of atherosclerosis. Pharmacological inhibition of PARP or reduced expression in heterozygous animals interferes with atherogenesis and may promote factors of plaque stability, po...

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מידע ביבליוגרפי
Main Authors: Hans, Chetan P., Zerfaoui, Mourad, Naura, Amarjit S., Troxclair, Dana, Strong, Jack P., Matrougui, Khalid, Boulares, A. Hamid
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Pharmacology and Experimental Therapeutics 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670599/
https://ncbi.nlm.nih.gov/pubmed/19124646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.145938
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