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Rapid Identification of the Hepatic Cytochrome P450 2C19 Activity Using a Novel and Noninvasive [(13)C]Pantoprazole Breath Test
We tested the hypothesis that the stable isotope [(13)C]pantoprazole is O-demethylated by cytochrome P450 CYP2C19 and that the (13)CO(2) produced and exhaled in breath as a result can serve as a safe, rapid, and noninvasive phenotyping marker of CYP2C19 activity in vivo. Healthy volunteers who had b...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670589/ https://ncbi.nlm.nih.gov/pubmed/19136640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.147751 |
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