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Rapid Identification of the Hepatic Cytochrome P450 2C19 Activity Using a Novel and Noninvasive [(13)C]Pantoprazole Breath Test

We tested the hypothesis that the stable isotope [(13)C]pantoprazole is O-demethylated by cytochrome P450 CYP2C19 and that the (13)CO(2) produced and exhaled in breath as a result can serve as a safe, rapid, and noninvasive phenotyping marker of CYP2C19 activity in vivo. Healthy volunteers who had b...

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書誌詳細
主要な著者: Desta, Zeruesenay, Modak, Anil, Nguyen, Phuong D., Lemler, Suzanne M., Kurogi, Yasuhisa, Li, Lang, Flockhart, David A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Pharmacology and Experimental Therapeutics 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670589/
https://ncbi.nlm.nih.gov/pubmed/19136640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.147751
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