Protective Effect of Geranylgeranylacetone via Enhancement of HSPB8 Induction in Desmin-Related Cardiomyopathy

BACKGROUND: An arg120gly (R120G) missense mutation in HSPB5 (α-β-crystallin ), which belongs to the small heat shock protein (HSP) family, causes desmin-related cardiomyopathy (DRM), a muscle disease that is characterized by the formation of inclusion bodies, which can contain pre-amyloid oligomer i...

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Autores principales: Sanbe, Atsushi, Daicho, Takuya, Mizutani, Reiko, Endo, Toshiya, Miyauchi, Noriko, Yamauchi, Junji, Tanonaka, Kouichi, Glabe, Charles, Tanoue, Akito
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670514/
https://ncbi.nlm.nih.gov/pubmed/19399179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005351
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