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Targeted Deletion of Tssk1 & 2 Causes Male Infertility Due to Haploinsufficiency

Targeted deletion of Tssk1 & 2 resulted in male chimeras which produced sperm/spermatogenic cells bearing the mutant allele, however this allele was never transmitted to offspring, indicating infertility due to haploinsufficiency. Morphological defects in chimeras included failure to form elonga...

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Detalhes bibliográficos
Main Authors: Xu, Bingfang, Hao, Zhonglin, Jha, Kula N., Zhang, Zhibing, Urekar, Craig, Digilio, Laura, Pulido, Silvia, Strauss, Jerome F, Flickinger, Charles J., Herr, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670491/
https://ncbi.nlm.nih.gov/pubmed/18533145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.03.047
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