Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma

BACKGROUND: Resistance of high-risk metastatic neuroblastoma (HR-NB) to high dose chemotherapy (HD-CT) raises a major therapeutic challenge in pediatric oncology. Patients are treated by maintenance CT. For some patients, an adjuvant retinoid therapy is proposed, such as the synthetic retinoid fenre...

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Hauptverfasser: Raguénez, Gilda, Mühlethaler-Mottet, Annick, Meier, Roland, Duros, Caroline, Bénard, Jean, Gross, Nicole
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670318/
https://ncbi.nlm.nih.gov/pubmed/19331667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-97
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