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Disulfide Bond Formation Significantly Accelerates the Assembly of Ure2p Fibrils because of the Proximity of a Potential Amyloid Stretch

Aggregation of the Ure2 protein is at the origin of the [URE3] prion trait in the yeast Saccharomyces cerevisiae. The N-terminal region of Ure2p is necessary and sufficient to induce the [URE3] phenotype in vivo and to polymerize into amyloid-like fibrils in vitro. However, as the N-terminal region...

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Bibliografiset tiedot
Päätekijät: Fei, Li, Perrett, Sarah
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670118/
https://ncbi.nlm.nih.gov/pubmed/19258323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809673200
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