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Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

Granulocytes generate a “respiratory burst” of NADPH oxidase-dependent superoxide anion (O(2)(−∙)) production that is required for efficient clearance of bacterial pathogens. Hv1 mediates a voltage-gated H(+) channel activity that is proposed to serve a charge-balancing role in granulocytic phagocyt...

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Detalles Bibliográficos
Main Authors: Ramsey, I. Scott, Ruchti, Evelyne, Kaczmarek, J. Stefan, Clapham, David E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669790/
https://ncbi.nlm.nih.gov/pubmed/19372380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902761106
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