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Type-II Kinase Inhibitor Docking, Screening, and Profiling Using Modified Structures of Active Kinase States

Type-II kinase inhibitors represent a class of chemicals that trap their target kinases in an inactive, so-called DFG-out, state, occupying a hydrophobic pocket adjacent to the ATP binding site. These compounds are often more specific than those targeting active, DFG-in, kinase conformations. Unfort...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Kufareva, Irina, Abagyan, Ruben
פורמט: Artigo
שפה:Inglês
יצא לאור: 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669721/
https://ncbi.nlm.nih.gov/pubmed/19053777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8010299
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