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Type-II Kinase Inhibitor Docking, Screening, and Profiling Using Modified Structures of Active Kinase States
Type-II kinase inhibitors represent a class of chemicals that trap their target kinases in an inactive, so-called DFG-out, state, occupying a hydrophobic pocket adjacent to the ATP binding site. These compounds are often more specific than those targeting active, DFG-in, kinase conformations. Unfort...
שמור ב:
| Main Authors: | , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669721/ https://ncbi.nlm.nih.gov/pubmed/19053777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8010299 |
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