Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo

Surfactant protein D (SP-D) is an important effector of innate immunity. We have previously shown that SP-D accumulates at sites of acute bacterial infection and neutrophil infiltration, a setting associated with the release of reactive species such as peroxynitrite. Incubation of native SP-D or tri...

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Main Authors: Matalon, Sadis, Shrestha, Kedar, Kirk, Marion, Waldheuser, Stephanie, McDonald, Barbara, Smith, Kelly, Gao, Zhiqian, Belaaouaj, Abderrazzak, Crouch, Erika C.
Format: Artigo
Sprog:Inglês
Udgivet: The Federation of American Societies for Experimental Biology 2009
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669423/
https://ncbi.nlm.nih.gov/pubmed/19126597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-120568
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