Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

Glucocorticoids, end products of the hypothalamic-pituitary-adrenal axis, influence functions of virtually all organs and tissues through the glucocorticoid receptor (GR). Circulating levels of glucocorticoids fluctuate naturally in a circadian fashion and regulate the transcriptional activity of GR...

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Bibliographische Detailangaben
Hauptverfasser: Nader, Nancy, Chrousos, George P., Kino, Tomoshige
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Federation of American Societies for Experimental Biology 2009
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669420/
https://ncbi.nlm.nih.gov/pubmed/19141540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-117697
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