Peripheral CLOCK Regulates Target-Tissue Glucocorticoid Receptor Transcriptional Activity in a Circadian Fashion in Man

CONTEXT AND OBJECTIVE: Circulating cortisol fluctuates diurnally under the control of the “master” circadian CLOCK, while the peripheral “slave” counterpart of the latter regulates the transcriptional activity of the glucocorticoid receptor (GR) at local glucocorticoid target tissues through acetyla...

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Detalhes bibliográficos
Main Authors: Charmandari, Evangelia, Chrousos, George P., Lambrou, George I., Pavlaki, Aikaterini, Koide, Hisashi, Ng, Sinnie Sin Man, Kino, Tomoshige
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182238/
https://ncbi.nlm.nih.gov/pubmed/21980503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025612
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